产品货号：
Z12465
中文名称：
Calreticulin/CALR抗体
英文名称：
Anti-Calreticulin/CALR Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Calreticulin/CALR Antibody |
| 指标别名 | CALR;Calregulin;calreticulin;cC1qR;CRP55;CRT;CRTC;ERp60;grp60;HACBP;RO;SSA |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,FCM,ELISA |
| 基因名称 | CALR |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Calreticulin/CALR recombinant protein (Position:E18-S323). |
| 实际分子量 | 60KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Calreticulin also known as°Calregulin,°CRP55,°CaBP3,°Calsequestrin-like protein,and endoplasmic reticulum resident protein 60 (ERp60) is a protein that in humans is encoded by the°CALR gene.It is mapped to 19p13.13.Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum.It is also found in the nucleus,suggesting that it may have a role in transcription regulation.Calreticulin binds to the synthetic peptide KLGFFKR,which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors.Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies,it is highly conserved among species,and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo,as well as retinoic acid-induced neuronal differentiation.Thus,calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors.Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen.Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven.Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. |
| Uniprot ID | P27797 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (ELISA)： 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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