产品货号：
Z12392
中文名称：
Caspase 3/CASP3 (p12)抗体
英文名称：
Anti-Caspase 3/CASP3 (p12) Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Caspase 3/CASP3 (p12) Antibody |
| 指标别名 | Apopain;CASP 3;CASP3;Caspase 3;Caspase 3/p17;Caspase3;CPP 32;CPP32;CPP32B;Cysteine protease CPP32;Protein Yama;SCA 1;SREBP cleavage activity 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | CASP3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminal of human Caspase 3(207-220aa RNSKDGSWFIQSLC),identical to the related mouse sequence,and different from the related rat sequence by one amino acid. |
| 实际分子量 | 35KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Caspase 3(caspase 3,apoptosis-related cysteine peptidase) is a caspase protein that interacts with caspase 8 and caspase 9,also known as Caspase-3,PARP CLEAVAGE PROTEASE,APOPAIN,CPP32,CPP32B,YAMA.It is a member of the cysteine-aspartic acid protease(caspase) family.PCR analysis of 16 human tissues revealed expression of full-length CASP3,as well as CASP3s at somewhat lower levels,in all tissues tested.Western blot analysis of 3 cell lines revealed the prominent CASP3 band at 32kD and CASP3s at 20kD.Several human cancer cell lines showed coexpression of both variants at the mRNA and protein levels.Overexpression of the catalytically inactive CASP3s by human kidney cells offered some resistance to inducers of apoptosis,and CASP3s accumulation could be enhanced with addition of proteasome inhibitors.Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.Alternative splicing of this gene results in two transcript variants that encode the same protein.Encoded by the CASP3 gene,CASP3 orthologs have been identified in numerous mammals for which complete genome data are available.Unique orthologs are also present in birds,lizards,lissamphibians,and teleosts.Nicholson et al.developed a potent peptide aldehyde inhibitor and showed that it prevented apoptotic events in vitro,suggesting that apopain/CPP32 is important for the initiation of apoptotic cell death. |
| Uniprot ID | P42574 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | caspase 3,apoptosis-related cysteine peptidase |
| 蛋白名全称 | Caspase-3(CASP-3) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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