产品货号：
Z12306
中文名称：
CBFB抗体
英文名称：
Anti-CBFB Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CBFB Antibody |
| 指标别名 | CBF beta;CBFB;PEA2 beta;PEBP2 beta;PEBP2B |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC/IF,FCM,ELISA |
| 基因名称 | CBFB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human CBFb recombinant protein (Position:M1-P182). |
| 实际分子量 | 22KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene.The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g.,RUNX1) and osteogenesis (e.g.,RUNX2).The beta subunit is a non-DNA binding regulatory subunit;it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters,including murine leukemia virus,polyomavirus enhancer,T-cell receptor enhancers and GM-CSF promoters.Alternative splicing generates two mRNA variants,each encoding a distinct carboxyl terminus.In some cases,a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11.This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype.Two transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | Q13951 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section 1:50～400 Immunocytochemistry in fixed cells 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (ELISA)： 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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