产品货号：
Z12052
中文名称：
BRSK1抗体
英文名称：
Anti-BRSK1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BRSK1 Antibody |
| 指标别名 | BR serine/threonine kinase 1;BRSK1;KIAA1811;SAD1;SAD1 kinase |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | BRSK1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | BRSK1 antibody was raised against a 28 amino acid synthetic peptide from near the carboxy terminus of human BRSK1.The immunogen is located within amino acids 720 - 770 of BRSK1. |
| 计算分子量 | 85kDa |
| 成分 | BRSK1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | BRSK1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | BRSK1 was initially identified as a mammalian homolog to the fission yeast S.pombe Cdr2,a mitosis-regulatory kinase and also shows significant homology to the C.elegans neuronal cell polarity regulator SAD1.BRSK1 is unbiquitously expressed,with highest levels of expression in the brain and testes.Similar to its yeast homolog,BRSK1 is thought to be involved in stress-induced cell cycle arrest.Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA,indicating its role in DNA damage checkpoint function.More recently,it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization.While BRSK1- and BRSK2-null mice were viable,double-mutant mice died within two hours of birth.Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites.These neurites also displayed both axonal and dendritic markers.At least two isoforms of BRSK1 are known to exist. |
| Uniprot ID | Q8TDC3 |
| 基因名全称 | BR serine/threonine kinase 1 |
| 蛋白名全称 | BR serine/threonine kinase 1 |
| 推荐稀释比 | BRSK1 antibody can be used for detection of BRSK1 by Western blot at 0.5 ～ 1μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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