产品货号：
Z12034
中文名称：
BRCC36/BRCC3抗体
英文名称：
Anti-BRCC36/BRCC3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BRCC36/BRCC3 Antibody |
| 指标别名 | BRCA1 A complex subunit BRCC36;BRCC3;BRCC36;BRISC complex subunit BRCC36;C6.1A;CXorf53 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,ICC/IF,FCM,ELISA |
| 基因名称 | BRCC3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human BRCC36/BRCC3 recombinant protein (Position:Q10-M276). |
| 实际分子量 | 36KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC),which is an E3 ubiquitin ligase.This complex plays a role in the DNA damage response,where it is responsible for the stable accumulation of BRCA1 at DNA break sites.The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains,and it regulates the abundance of these polyubiquitin chains in chromatin.The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya,a cerebrovascular angiopathy.Alternative splicing results in multiple transcript variants.A related pseudogene has been identified on chromosome 5. |
| Uniprot ID | P46736 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | BRCA1/BRCA2-containing complex subunit 3 |
| 蛋白名全称 | Lys-63-specific deubiquitinase BRCC36 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells ELISA 1:100～1000 |
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