产品货号:
Z11688
中文名称:
ATF6抗体
英文名称:
Anti-ATF6 Antibody
产品规格:
0.1mg
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-ATF6 Antibody |
指标别名 | ATF6;ATF6 alpha;ATF6A |
克隆性 | Polyclonal |
检验物种 | human,mouse |
应用范围 | ELISA,WB,IHC,ICC,IF |
基因名称 | ATF6 |
抗体来源 | Rabbit |
抗体类型 | IgG |
免疫原 | ATF6 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ATF6.The immunogen is located within amino acids 470 - 520 of ATF6. |
计算分子量 | 75kDa |
成分 | ATF6 Antibody is supplied in PBS containing 0.02% sodium azide. |
纯化方式 | ATF6 Antibody is affinity chromatography purified via peptide column. |
浓度 | 1mg/mL |
产品形态 | 溶液 |
保存条件 | 4℃可保存3个月,-20℃可保存1年。 |
背景资料 | Disruptions of protein folding and maturation in the endoplasmic reticulum (ER) result in the activation of the unfolded protein response (UPR),an integrated cellular signaling pathway that transmits information from the ER lumen to the cytoplasm and nucleus.Activating transcription factor 6 (ATF6) as well as the ER-transmembrane protein kinases IRE1p and PERK are the major transducers of the UPR.ATF6 is an ER transmembrane protein that is normally bound to the ER chaperone GRP78,but upon ER stress is released from GRP78 and proteolytically cleaved to yield a cytosolic fragment which then migrates to the nucleus,and together with the transcription factor XBP-1,activates transcription of UPR-responsive genes.ATF6 has two isoforms (ATF6汐and ATF6汕);only ATF6汐is recognized by this antibody. |
Uniprot ID | P18850 |
基因名全称 | Activating transcription factor 6 |
蛋白名全称 | Activating transcription factor 6 |
推荐稀释比 | ATF6 antibody can be used for the detection of ATF6 by Western blot at 0.5 ~ 1μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL and immunocytochemistry starting at 10μg/mL.For immunofluorescence start at 10μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in human samples;Immunocytochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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