产品货号：
Z11534
中文名称：
Beclin 1/BECN1抗体
英文名称：
Anti-Beclin 1/BECN1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Beclin 1/BECN1 Antibody |
| 指标别名 | ATG6;Beclin 1;beclin 1;autophagy related;beclin1;BECN1;GT197;Protein GT197;VPS30;Beclin-1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | BECN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human Beclin 1(222-237aa LDQEEAQYQREYSEFK),identical to the related rat and mouse sequences. |
| 实际分子量 | 52～60KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Bellini-1(beclin 1,autophagy related) is a protein that in humans is encoded by the BECN1 gene,also known as BECN1,ATG6,VPS30,Coiled-coil myosin-like BCL2-interacting protein,Protein GT197,autophagy-related gene(Atg) 6.Beclin-1 and its binding partner class III phosphoinositide 3-kinase(PI3K),also named Vps34,are required for the initiation of the formation of the autophagosome in autophagy.Human beclin encodes a novel 450-amino acid protein containing a coiled-coil region,within which it has limited homology to myosin-like proteins.Northern blot analysis of mouse and adult human tissues revealed widespread beclin expression.A 2.2-kb transcript was present at highest levels in human skeletal muscle and at detectable levels in all tissues examined.In some tissues,additional 1.7- and 1.4-kb transcripts were observed,suggesting the presence of alternatively spliced transcripts.Immunoperoxidase staining of human hippocampus and frontal cortex sections revealed beclin immunoreactivity in many neurons throughout these regions,as well as in some glial cells.Beclin protects against infection by a neurovirulent strain of Sindbis virus that is known to overcome the protective effects of Bcl2.Liang et al.showed that beclin reduced Sindbis virus replication in mouse brain and reduced Sindbis virus-induced cell death in mouse brain. |
| Uniprot ID | Q14457 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1866) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | beclin 1,autophagy related |
| 蛋白名全称 | Beclin-1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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