产品货号：
Z11522
中文名称：
Beclin 1/BECN1抗体
英文名称：
Anti-Beclin 1/BECN1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Beclin 1/BECN1 Antibody |
| 指标别名 | ATG6;Beclin 1;beclin 1;autophagy related;beclin1;BECN1;GT197;Protein GT197;VPS30;Beclin-1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,ICC,IF |
| 基因名称 | BECN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Beclin-1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Beclin-1.The immunogen is located within the last 50 amino acids of Beclin-1. |
| 计算分子量 | 52kDa |
| 成分 | Beclin-1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | Beclin-1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Beclin-1 antibody can be stored at 4℃ up to one year.Antibodies should not be exposed to prolonged high temperatures. |
| 背景资料 | Autophagy,the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells.Beclin-1,a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6,is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma,suggesting that defects in autophagy proteins may contribute to the development or progression of tumors.Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells,suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein,which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death. |
| Uniprot ID | Q14457 |
| 基因名全称 | Beclin 1,autophagy related |
| 蛋白名全称 | Beclin 1,autophagy related |
| 推荐稀释比 | Beclin-1 antibody can be used for the detection of Beclin-1 by Western blot at 0.5 ～ 2μg/mL.Antibody can also be used for immunocytochemistry starting at 1μg/mL.For immunofluorescence start at 2μg/mL.Antibody validated:Western Blot in human samples;Immunocytochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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