产品货号：
Z11474
中文名称：
BACH2抗体
英文名称：
Anti-BACH2 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BACH2 Antibody |
| 指标别名 | Bach2,Bach-2,Bach 2,BTB and CNC homology 1,basic leucine zipper transcription factor 2 |
| 克隆性 | Polyclonal |
| 检验物种 | mouse |
| 应用范围 | ELISA,IP,WB |
| 基因名称 | BACH2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-Bach2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the n-terminus region of the Bach2 protein. |
| 计算分子量 | 92kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | Bach2 antibody is directed against mouse Bach2 (n-terminus) protein.Anti-Bach-2 was affinity purified from monospecific antiserum by immunoaffinity purification.A BLAST analysis was used to suggest 100% homology with Bach2 protein from mouse.Reactivity against homologues from other sources is not known. |
| 浓度 | 0.97mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | This antibody is suitable for Cancer and DNA Damage & Repair research.During an immune response to infectious diseases and cancer,B-cells undergo activation in response to antigen,and differentiate either into short-lived plasma cells,whose numbers contract following withdrawal of the antigenic stimulus,or into memory B-cells.The formation of B-cell memory is the major goal of vaccination,since memory B-cells are able to produce antibodies specific to infections and cancer that can last for the lifetime of the host.Recently it has been shown that the formation of long-lived memory B-cells is dependent upon the transcription factor Bach2,since knockout mice lacking the gene fail to generate class-switched IgG antibody responses and all B-cells undergo default plasma cell differentiation upon antigenic stimulation.While the mechanism by which Bach2 controls B-cell memory fate has been elucidated (it binds and represses the promoter of the gene that encodes the plasma cell master regulatory transcription factor Blimp-1),the upstream mechanism by which the function of Bach2 is regulated is unknown.There is evidence suggesting that Bach2 is phosphorylated in B-cells following stimulation and suspect that this modification may allow the B-cell signaling apparatus to control Bach2 activity and therefore memory fate decisions.Anti-Bach2 is ideal for researchers interested in Cancer and DNA Damage & Repair research. |
| Uniprot ID | A2RRI0 |
| 基因名全称 | Transcription regulator protein BACH2 |
| 推荐稀释比 | ELISA:1:5000 IP:1μg/mL WB:1μg/mL |
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