产品货号：
Z11422
中文名称：
ATM抗体
英文名称：
Anti-ATM Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ATM Antibody |
| 指标别名 | A T mutated;AT1;ATA;ataxia telangiectasia mutated;ATC;ATD;ATDC;ATE;ATM;Serine protein kinase ATM;TEL1;TELO1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | ATM |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | ATM antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human ATM.The immunogen is located within amino acids 2970 - 3020 of ATM. |
| 计算分子量 | 351kDa |
| 成分 | ATM Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | ATM Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | DNA double strand breaks represent a major threat to an organism's genome.Eukaryotic cells have developed mechanisms that sense the presence this damage and initiate suitable responses that can include DNA repair,cell cycle delay,and programmed cell death.The ATM (mutated in Ataxia-Telangiectasia) protein kinase is activated following the formation of DNA double strand breaks,phosphorylating p53 and another kinase CHK2.This initiates a signaling cascade leading to the phosphorylation and inhibition of Cdc25,ultimately preventing cell cycle progression.In some cell types,such as the hemapoietic system,this leads to apoptosis instead of cell cycle arrest.Multiple isoforms of ATM are known to exist. |
| Uniprot ID | Q13315 |
| 基因名全称 | Ataxia telangiectasia mutated |
| 蛋白名全称 | Ataxia telangiectasia mutated |
| 推荐稀释比 | ATM antibody can be used for detection of ATM by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 10μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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