产品货号：
Z11167
中文名称：
ASK1/MAP3K5抗体
英文名称：
Anti-ASK1/MAP3K5 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ASK1/MAP3K5 Antibody |
| 指标别名 | ASK 1;ASK1;MAP3K5;MAPK/ERK kinase kinase 5;MAPKKK5;MEK kinase 5;MEKK 5;MEKK5 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | MAP3K5 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human ASK1/MAP3K5 recombinant protein (Position:A178-K1112). |
| 实际分子量 | 155KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway.Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK),MAPK kinase (MKK or MEK),and MAPK kinase kinase (MAPKKK or MEKK).MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,MAPK kinase/MEK,which in turn activates MAPK.The kinases of these signaling cascades are highly conserved,and homologs exist in yeast,Drosophila,and mammalian cells.MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains.Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas.The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1,MAPKK4) in vitro,and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells;MAPKKK5 does not activate MAPK/ERK. |
| Uniprot ID | Q99683 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | mitogen-activated protein kinase kinase kinase 5 |
| 蛋白名全称 | Mitogen-activated protein kinase kinase kinase 5 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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