产品货号：
Z11100
中文名称：
APH1A抗体
英文名称：
Anti-APH1A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-APH1A Antibody |
| 指标别名 | 6530402N02Rik;APH 1A;Aph 1alpha;APH1A;CGI 78;Gamma secretase subunit APH 1A;PSF;UNQ579/PRO1141 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | APH1A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human APH1a (236-265aa LRSIQRSLLCRRQEDSRVMVYSALRIPPED),different from the related mouse sequence by one amino acid. |
| 实际分子量 | 29KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | APH1a encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein.The gamma secretase complex contains this gene product,or the paralogous anterior pharynx defective 1 homolog B (APH1B),along with the presenilin,nicastrin,and presenilin enhancer-2 proteins.The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing.Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease.Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. |
| Uniprot ID | Q96BI3 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | APH1A gamma secretase subunit |
| 蛋白名全称 | Gamma-secretase subunit APH-1A |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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