产品货号：
Z10730
中文名称：
Alpha B Crystallin/CRYAB抗体
英文名称：
Anti-Alpha B Crystallin/CRYAB Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Alpha B Crystallin/CRYAB Antibody |
| 指标别名 | Alpha B Crystallin;Alpha crystallin B chain;Alpha(B) crystallin;CRYA2;CRYAB;crystallin;alpha B;CTPP2;Heat shock protein beta 5;HSPB5;Rosenthal fiber component |
| 克隆性 | Polyclonal |
| 检验物种 | human,monkey,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | CRYAB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Alpha B Crystallin/CRYAB recombinant protein (Position:E30-Q151). |
| 实际分子量 | 20KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene.Mammalian lens crystallins are divided into alpha,beta,and gamma families.Alpha crystallins are composed of two gene products:alpha-A and alpha-B,for acidic and basic,respectively.Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family.They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone;instead they hold them in large soluble aggregates.These heterogeneous aggregates consist of 30-40 subunits;the alpha-A and alpha-B subunits have a 3:1 ratio,respectively.Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture.The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions.Alpha-A and alpha-B gene products are differentially expressed;alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs.Elevated expression of alpha-B crystallin occurs in many neurological diseases;a missense mutation cosegregated in a family with a desmin-related myopathy.Alternative splicing results in multiple transcript variants. |
| Uniprot ID | P02511 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | crystallin alpha B |
| 蛋白名全称 | Alpha-crystallin B chain |
| 推荐稀释比 | Western blot (WB) 1:2000～8000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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