产品货号：
Z10691
中文名称：
ALKBH2抗体
英文名称：
Anti-ALKBH2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ALKBH2 Antibody |
| 指标别名 | ABH2;ABH2;Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2;Alkylated DNA repair protein alkB homolog 2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC |
| 基因名称 | ALKBH2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | ALKBH2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ALKBH2.The immunogen is located within amino acids 180 - 230 of ALKBH2. |
| 计算分子量 | 29kDa |
| 成分 | ALKBH2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | ALKBH2 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | The E.coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA;ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine,modifications that left unchecked could lead to cancerous cells.Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation.Like the histone demethylase JMJD1A,ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions,suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer.Conversely,ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy,an adjuvant therapy in cancer treatment,suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment. |
| Uniprot ID | Q6NS38 |
| 基因名全称 | AlkB,alkylation repair homolog 2 (E.coli) |
| 蛋白名全称 | AlkB,alkylation repair homolog 2 (E.coli) |
| 推荐稀释比 | ALKBH2 antibody can be used for detection of ALKBH2 by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 10μg/mL.Antibody validated:Western Blot in human samples and Immunohistochemistry in human samples.All other applications and species not yet tested. |
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