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所在位置:所有产品 > 抗体抗原 > 一抗 > ADAM17抗体
ADAM17抗体图片
产品货号:
Z10280
中文名称:
ADAM17抗体
英文名称:
Anti-ADAM17 Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-ADAM17 Antibody
指标别名ADAM 17;ADAM17;CD156b;cSVP;Snake venom like protease;TACE;TNF alpha convertase;TNF alpha converting enzyme
克隆性Polyclonal
检验物种human,mouse,rat
应用范围WB
基因名称ADAM17
抗体来源Rabbit
抗体类型IgG
免疫原A synthetic peptide corresponding to a sequence at the C-terminus of human ADAM17(806-824aa AASFKLQRQNRVDSKETEC),different from the related rat and mouse sequences by one amino acid.
实际分子量93KD
成分500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol.
纯化方式Immunogen affinity purified.
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料ADAM17(ADAM metallopeptidase domain 17),also called TACE (tumor necrosis factor-alpha-converting enzyme),is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases.Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-alpha to its mature form.Northern blot analysis revealed that the gene was expressed as a 5-kb mRNA in all tissues examined.ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha(TNF-alpha) at the surface of the°Cell,and from within theintracellular membranes of the trans-Golgi network.This process,which is also known as "shedding",involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins(such as pro-TNF-alpha),and is of known physiological importance.ADAM17 was the first "sheddase" to be identified,and is also understood to play a role in the release of a diverse variety of membrane-anchored°Cytokines,°Cell adhesion molecules,receptors,ligands,and enzymes.
Uniprot IDP78536
推荐配套试剂Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。
基因名全称ADAM metallopeptidase domain 17
蛋白名全称Disintegrin and metalloproteinase domain-containing protein 17(ADAM 17)
推荐稀释比
Western blot(WB) 1:500~2000

相关搜索:ADAM17抗体ADAM17多抗Anti-ADAM17 Antibody
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