产品货号：
Z10241
中文名称：
AIM2抗体
英文名称：
Anti-AIM2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-AIM2 Antibody |
| 指标别名 | absent in melanoma 2;AIM2;PYHIN4 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | AIM2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human AIM2 recombinant protein (Position:L14-H215).Human AIM2 shares 53.8% amino acid (aa) sequence identity with mouse AIM2. |
| 实际分子量 | 45KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Interferon-inducible protein AIM2,also known as absent in melanoma 2 or simply AIM2,is a protein that in humans is encoded by the AIM2 gene.It is mapped to 1q22.AIM2 is a member of the Ifi202/IFI16 family.It plays a putative role in tumorigenic reversion and may control cell proliferation.Interferon-gamma induces expression of AIM2.Though there has been virtually no biochemistry performed,a model based on cell-based or in vivo experiments has led to the current model of how AIM2 triggers the inflammasome.The C-terminal HIN domain binds double stranded DNA (either viral,bacterial,or even host) and acts as a cytosolic dsDNA sensor.This leads to the oligomerization of the inflammasome complex.The N-terminal pyrin domain of AIM2 interacts with the pyrin domain of another protein ASC (or Apoptosis-associated Speck-like protein containing a caspase activation and recruitment domain).ASC also contains a°CARD domain (caspase activation and recruitment domain),that recruits procaspase-1 to the complex.This leads to the autoactivation of°Caspase-1,an enzyme that processes proinflammatory°Cytokines (IL-1b and IL-18). |
| Uniprot ID | O14862 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | absent in melanoma 2 |
| 蛋白名全称 | Interferon-inducible protein AIM2 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry(Paraffin-embedded Section) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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