产品货号：
Z10224
中文名称：
AIM2抗体
英文名称：
Anti-AIM2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-AIM2 Antibody |
| 指标别名 | absent in melanoma 2;AIM2;PYHIN4 |
| 克隆性 | Polyclonal |
| 检验物种 | mouse |
| 应用范围 | WB,FCM,ELISA |
| 基因名称 | AIM2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived mouse Aim2 recombinant protein (Position:Q136-E354). |
| 实际分子量 | 45KD |
| 成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Interferon-inducible protein AIM2,?also known as?absent in melanoma 2?or simply?AIM2,?is a?protein?that in humans is encoded by the?AIM2?gene.It is mapped to 1q22.AIM2 is a member of the?Ifi202/IFI16?family.It plays a putative role in tumorigenic reversion and may control cell proliferation.?Interferon-gamma?induces expression of AIM2.Though there has been virtually no biochemistry performed,a model based on cell-based or in vivo experiments has led to the current model of how AIM2 triggers the inflammasome.The C-terminal HIN domain binds double stranded DNA?(either viral,bacterial,or even host) and acts as a cytosolic dsDNA sensor.This leads to the oligomerization of the inflammasome complex.The N-terminal pyrin domain of AIM2 interacts with the pyrin domain of another protein?ASC?(or Apoptosis-associated Speck-like protein containing a caspase activation and recruitment domain).ASC also contains a?CARD domain?(caspase activation and recruitment domain),that recruits procaspase-1 to the complex.This leads to the autoactivation of?caspase-1,an enzyme that processes proinflammatory?cytokines?(IL-1b?and?IL-18). |
| Uniprot ID | Q91VJ1 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | absent in melanoma 2 |
| 蛋白名全称 | Interferon-inducible protein AIM2 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 (ELISA)： 1:100～1000 |
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