产品货号：
Z10041
中文名称：
AAZIN2抗体
英文名称：
Anti-AAZIN2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-AAZIN2 Antibody |
| 指标别名 | 5 azacytidine induced 2;AZ2;AZI2;AZI2/NAP1;Nak associated protein 1;NAP1;TILP |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | AZIN2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human AZIN2 recombinant protein (Position:C111-Q301).Human AZIN2 shares 89.4% amino acid (aa) sequence identity with mouse AZIN2. |
| 实际分子量 | 50KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Antizyme inhibitor 2 (AzI2),also known as arginine decarboxylase (ADC),is an enzyme that in humans is encoded by the AZIN2 gene.The protein encoded by this gene belongs to the antizyme inhibitor family,which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell.Antizyme inhibitors are homologs of ornithine decarboxylase (ODC,the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine;however,retain the ability to bind to antizymes.Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation,as well as by inhibiting polyamine uptake.Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect.This gene encodes antizyme inhibitor 2,the second member of this gene family.Like antizyme inhibitor 1,antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake.However,unlike antizyme inhibitor 1,which is ubiquitously expressed and localized in the nucleus and cytoplasm,antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment.Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries,adrenal glands and pancreas,and in mast cells.The exact function of this gene is not known,however,available data suggest its role in cell growth,spermiogenesis,vesicular trafficking and secretion. |
| Uniprot ID | Q96A70 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | antizyme inhibitor 2 |
| 蛋白名全称 | Antizyme inhibitor 2 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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