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产品目录

小鼠抗Sequestosome-1抗体图片
产品货号:
YT757
中文名称:
小鼠抗Sequestosome-1抗体
英文名称:
Sequestosome-1 Mouse Monoclonal Antibody
产品规格:
50μl
发货周期:
1~3天
产品价格:
询价
本品为来源于小鼠的抗Sequestosome-1的单克隆抗体。
宿主:小鼠
克隆性:单克隆抗体
用途:WB,FC, IHC,ICC, IF
交叉反应性:人,小鼠,大鼠
分子量:62KDa
推荐稀释比例:WB(1:500-1:1000),IF(1:200),IHC(1:200),ICC(1:200),FC(1:50-1:100)

About this Antibody
Name Sequestosome-1 Mouse Monoclonal Antibody
Category Monoclonal antibody(mAb); Primary antibody
Isotype IgG1
Purification ProA affinity purified
About the Immunogen
Immunogen This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to SQSTM1.
Gene ID 8878
SwissProt Q13501
Synonyms OSIL antibody; Oxidative stress induced like antibody p60 antibody p62 antibody p62B antibody Paget disease of bone 3 antibody PDB 3 antibody PDB3 antibody
Category Autophagy
Background Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress and autophagy. It was first identified as a protein that binds to the SH2 domain of p56Lck and independently found to interact with PKCζ. SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome. Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-κB pathway. It may play a role in titin/TTN downstream signaling in muscle cells and regulate signaling cascades through ubiquitination. P62 may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.


注意事项:
1. 如果本抗体用于Western blot (WB)、免疫荧光(IF)、免疫细胞化学(ICC)等实验,请注意回收使用过的稀释抗体。回收的抗体通常至少可以重复使用5-10次。稀释后的抗体,包括已经使用过的稀释抗体,请4℃保存。
2. 回收后重复使用的抗体,使用方法同新鲜稀释的抗体。如果在重复使用过程中发现抗体出现轻微混浊现象,可以10,000g离心1-3分钟,取上清用于后续检测。如果回收的抗体出现明显的絮状物或长霉长菌等情况,则可以考虑废弃该抗体。
3. 提供的Western一抗稀释液也可以用于免疫荧光(IF)、免疫组化(IHC)、免疫细胞化学(ICC)等适当用途。如果希望获得最佳的检测效果,请考虑使用上述检测专用的一抗稀释液。

储存条件:-20℃,有效期一年。
相关搜索:小鼠抗Sequestosome-1抗体Sequestosome-1 Mouse Monoclonal Antibody
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