产品货号：
GS4630
中文名称：
重组人Maspin
英文名称：
Recombinant Human Mammary Serine Protease Inhibitor
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 42.1kDa,a single non-glycosylated polypeptide chain containing 375 amino acid residues.
储存条件：冷冻（-20℃）
概述
Mammary serine protease inhibitor(Maspin),also known as serpin B5 is a non-inhibitory serpin that is encoded by the SERPINB5 gene in humans.The protein is expressed predominantly in normal mammary epithelial cells but at significantly reduced levels or absent in most breast carcinomas.As it does not undergo the S(stressed)to R(relaxed)conformational transition characteristic of active serpins,it exhibits no serine protease inhibitory activity.The maspin functions as tumor suppressor,blocking the growth,invasion,and metastatic properties of mammary tumors.This anti-tumor activity is achieved,in part,by the ability of maspin to inhibit angiogenesis and to preferentially promote apoptosis of tumor cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人Maspin，Maspin, Human
储存条件：冷冻（-20℃）
概述
Mammary serine protease inhibitor(Maspin),also known as serpin B5 is a non-inhibitory serpin that is encoded by the SERPINB5 gene in humans.The protein is expressed predominantly in normal mammary epithelial cells but at significantly reduced levels or absent in most breast carcinomas.As it does not undergo the S(stressed)to R(relaxed)conformational transition characteristic of active serpins,it exhibits no serine protease inhibitory activity.The maspin functions as tumor suppressor,blocking the growth,invasion,and metastatic properties of mammary tumors.This anti-tumor activity is achieved,in part,by the ability of maspin to inhibit angiogenesis and to preferentially promote apoptosis of tumor cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Data is not available. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuMaspin as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDIPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFPESET KECPFRLNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSMFI LL |
相关搜索：重组人Maspin，Maspin, Human